CP-640186 | 9422

CP-640186 is a mixed ACC (Acetyl-CoA carboxylase) inhibitor (ACC-1 IC₅₀ = 53 nM; ACC-2 IC₅₀ = 61 nM) that lowers malonyl-CoA levels and inhibits hepatic fatty acid and triglyceride synthesis in vitro and in vivo, as well as stimulates muscle fatty acid oxidation and lowers whole body RQ in rats.

CP-640186 is a mixed ACC (Acetyl-CoA carboxylase) inhibitor (ACC-1 IC₅₀ = 53 nM; ACC-2 IC₅₀ = 61 nM) that lowers malonyl-CoA levels and inhibits hepatic fatty acid and triglyceride synthesis in vitro and in vivo, as well as stimulates muscle fatty acid oxidation and lowers whole body RQ in rats.

9422 | CP-640186 DataSheet

Alternate Name/Synonyms: [(3R)​-​​1'-​​(9-​​anthracenylcarbonyl)​[1,​​4'-​​bipiperidin]​-​​3-​​yl]​-​​4-​​morpholinyl-​methanone

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 591778-68-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₃₅N₃O₃

Molecular Weight: 485.62

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A mixed ACC (Acetyl-CoA carboxylase) inhibitor

MDL Number: N/A

PubChem CID: 449097

SMILES: C1CC(CN(C1)C2CCN(CC2)C(=O)C3=C4C=CC=CC4=CC5=CC=CC=C53)C(=O)N6CCOCC6

InChi: InChI=1S/C30H35N3O3/c34-29(32-16-18-36-19-17-32)24-8-5-13-33(21-24)25-11-14-31(15-12-25)30(35)28-26-9-3-1-6-22(26)20-23-7-2-4-10-27(23)28/h1-4,6-7,9-10,20,24-25H,5,8,11-19,21H2/t24-/m1/s1

InChi Key: LDQKDRLEMKIYMC-XMMPIXPASA-N