Description
CP-640186 is a mixed ACC (Acetyl-CoA carboxylase) inhibitor (ACC-1 IC₅₀ = 53 nM; ACC-2 IC₅₀ = 61 nM) that lowers malonyl-CoA levels and inhibits hepatic fatty acid and triglyceride synthesis in vitro and in vivo, as well as stimulates muscle fatty acid oxidation and lowers whole body RQ in rats.
CP-640186 is a mixed ACC (Acetyl-CoA carboxylase) inhibitor (ACC-1 IC₅₀ = 53 nM; ACC-2 IC₅₀ = 61 nM) that lowers malonyl-CoA levels and inhibits hepatic fatty acid and triglyceride synthesis in vitro and in vivo, as well as stimulates muscle fatty acid oxidation and lowers whole body RQ in rats.
Alternate Name/Synonyms: [(3R)-1'-(9-anthracenylcarbonyl)[1,4'-bipiperidin]-3-yl]-4-morpholinyl-methanone
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 591778-68-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₀H₃₅N₃O₃
Molecular Weight: 485.62
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A mixed ACC (Acetyl-CoA carboxylase) inhibitor
MDL Number: N/A
PubChem CID: 449097
SMILES: C1CC(CN(C1)C2CCN(CC2)C(=O)C3=C4C=CC=CC4=CC5=CC=CC=C53)C(=O)N6CCOCC6
InChi: InChI=1S/C30H35N3O3/c34-29(32-16-18-36-19-17-32)24-8-5-13-33(21-24)25-11-14-31(15-12-25)30(35)28-26-9-3-1-6-22(26)20-23-7-2-4-10-27(23)28/h1-4,6-7,9-10,20,24-25H,5,8,11-19,21H2/t24-/m1/s1
InChi Key: LDQKDRLEMKIYMC-XMMPIXPASA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |