LBD
CPLX2 Antibody (Center) [APR11654G]
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- LBD-APR11654G
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Description
CPLX2 Antibody (Center) [APR11654G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M
Specificity: This CPLX2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 51-83 amino acids from the Central region of human CPLX2.
Cellular Localisation: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P84087}. Cell junction, synapse, presynapse {ECO:0000250|UniProtKB:P84087}. Nucleus {ECO:0000250|UniProtKB:P84087} Perikaryon {ECO:0000250|UniProtKB:P84087}. Note=Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation. {ECO:0000250|UniProtKB:P84087}
Molecular Weight: 15394
Clone: Polyclonal
Gene Name: CPLX2
Gene ID: 10814
Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity) .
Summary: Tissue Location: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Complexin-2, Complexin II, CPX II, Synaphin-1, CPLX2