CREB3L3 Antibody (Center) [APR33336G]

CREB3L3 Antibody (Center) [APR33336G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This CREB3L3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 244-274 amino acids of human CREB3L3.

Cellular Localisation: Endoplasmic reticulum membrane; Single-pass type II membrane protein

Molecular Weight: 49077

Clone: Polyclonal

Gene Name: CREB3L3

Gene ID: 84699

Function: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity) . May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription (By similarity) .

Summary: Tissue Location: Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000-1:2000

Synonyms: Cyclic AMP-responsive element-binding protein 3-like protein 3, cAMP-responsive element-binding protein 3-like protein 3, Transcription factor CREB-H, Processed cyclic AMP-responsive element-binding protein 3-like protein 3, CREB3L3, CREBH