CRIM1 Antibody | 6961

CRIM1 Antibody | 6961 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Mouse: (88%)

Immunogen: CRIM1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Crim1.
The immunogen is located within amino acids 910 - 960 of CRIM1.

Research Area: Stem Cell

Tested Application: E, WB, IF

Application: CRIM1 antibody can be used for detection of Crim1 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: CRIM1 antibody is human reactive. CRIM1 antibody is predicted to not cross-react with CRIM2.

Positive Control 1: Cat. No. 1205 - Jurkat Cell Lysate

Positive Control 2: Cat. No. 17-005 - Jurkat Cell Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: CRIM1 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: CRIM1 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: CRIM1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: CRIM1 Antibody: S52, CRIM-1, S52, UNQ1886/PRO4330, Cysteine-rich motor neuron 1 protein, Cysteine-rich repeat-containing protein S52

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CRIM1 Antibody: CRIM1 (cysteine-rich motor neuron 1) , a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.