CRLF2 polyclonal Antibody | BS70875

CRLF2 polyclonal Antibody | BS70875 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:200 - 1:1000

Background: The gene encoding murine TSLP maps to chromosome 18. Its human homologue is expressed in several tissues, including heart, liver and prostate. TSLP mediates its function by binding to a receptor complex: first binding with low affinity to a TSLP-specific chain designated TSLPR, (also designated CRLF2, cytokine receptor-like factor 2), then forming a high affinity complex with the IL-7Ra subunit, which explains the overlapping biological properties between TSLP and IL-7. Both TSLP and IL-7 induce phosphorylation of the transcription factor Stat5, but unlike IL-7, TSLP-mediated signaling does not activate the JAKs. TSLP prevents apoptosis and stimulates the proliferation of myeloid cells, which is supported by the coexpression of TSLPR and IL-7Ra on monocytes and dendritic cells.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CRLF2 polyclonal Antibody detects endogenous levels of CRLF2 protein.

Molecular Weight: ~ 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CRL2; ILXR; TSLPR; TSLP receptor; Cytokine receptor-like 2; IL-XR

Immunogen: Recombinant protein of human CRLF2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: