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CRLF2 polyclonal Antibody | BS70875
- SKU:
- BW-BS70875
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- Usually ships in 5 working days
Description
CRLF2 polyclonal Antibody | BS70875 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB
Application Range: WB 1:200 - 1:1000
Background: The gene encoding murine TSLP maps to chromosome 18. Its human homologue is expressed in several tissues, including heart, liver and prostate. TSLP mediates its function by binding to a receptor complex: first binding with low affinity to a TSLP-specific chain designated TSLPR, (also designated CRLF2, cytokine receptor-like factor 2), then forming a high affinity complex with the IL-7Ra subunit, which explains the overlapping biological properties between TSLP and IL-7. Both TSLP and IL-7 induce phosphorylation of the transcription factor Stat5, but unlike IL-7, TSLP-mediated signaling does not activate the JAKs. TSLP prevents apoptosis and stimulates the proliferation of myeloid cells, which is supported by the coexpression of TSLPR and IL-7Ra on monocytes and dendritic cells.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CRLF2 polyclonal Antibody detects endogenous levels of CRLF2 protein.
Molecular Weight: ~ 50 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CRL2; ILXR; TSLPR; TSLP receptor; Cytokine receptor-like 2; IL-XR
Immunogen: Recombinant protein of human CRLF2.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: