Description
CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain multiple cystatin like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. This protein is able to form a dimer stabilized by noncovalent forces and is thought to play a role in protecting against the proteases leaking from lysosomes. In cells, CSTB is located in the lysosomes and the cytoplasm, but also in the nucleus.
9235 | CSTB human recombinant DataSheet
Biomolecule/Target: CSTB
Synonyms: Cystatin-B, Stefin B, PME, CST6
Alternates names: BMP4, ZYME, BMP2B, BMP2B1
Taglines: An anti-protease implicated in myoclonus epilepsy.
NCBI Gene ID #: 652
NCBI Gene Symbol: BMP 4
Gene Source: Human
Accession #: P12644
Recombinant: Yes
Source: E.coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: >95%
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: s recombinant human BMP-4 is biologically active. The ED as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 µg/ml.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 13.0 kDa
Concentration: 1 mg/ml
Appearance: Liquid
Physical form description: Liquid
Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in sterile 20 mM acetic acid. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A