CSTB, human recombinant | 9235

CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain multiple cystatin like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. This protein is able to form a dimer stabilized by noncovalent forces and is thought to play a role in protecting against the proteases leaking from lysosomes. In cells, CSTB is located in the lysosomes and the cytoplasm, but also in the nucleus.

9235 | CSTB human recombinant DataSheet

Biomolecule/Target: CSTB

Synonyms: Cystatin-B, Stefin B, PME, CST6

Alternates names: BMP4, ZYME, BMP2B, BMP2B1

Taglines: An anti-protease implicated in myoclonus epilepsy.

NCBI Gene ID #: 652

NCBI Gene Symbol: BMP 4

Gene Source: Human

Accession #: P12644

Recombinant: Yes

Source: E.coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: >95%

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: ’s recombinant human BMP-4 is biologically active. The ED as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 µg/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 13.0 kDa

Concentration: 1 mg/ml

Appearance: Liquid

Physical form description: Liquid

Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in sterile 20 mM acetic acid. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A