CTCFL Antibody | 22-033

CTCFL Antibody | 22-033 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CTCFL (NP_001255970.1) .

Research Area: Cancer, Transcription

Tested Application: WB, IF

Application: WB: 1:500 - 1:2000
IF: 1:20 - 1:100

Specificiy: N/A

Positive Control 1: Jurkat

Positive Control 2: HeLa

Positive Control 3: Mouse heart

Positive Control 4: Rat testis

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 68kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: CTCFL, CT27, BORIS, CTCF-T, HMGB1L1, dJ579F20.2

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: CCCTC-binding factor (CTCF) , an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.