Description
CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by mbilical vein and Vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF 1, and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Recombinant human CTGF is a 11.2 kDa protein of 98 amino acid residues.
4702 | CTGF human recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: Connective Tissue Growth Factor, CCN2, Hypertrophic chondrocyte-specific protein 24 (HCS24)
Alternates names: Osteogenic Protein 1, BMP-7
Taglines: A major mitogenic and chemoattractant protein produced by umbilical vein and Vascular endothelial cells
NCBI Gene ID #: 655
NCBI Gene Symbol: BMP 7
Gene Source: Human
Accession #: P18075
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: 95%
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: s recombinant human BMP-7 is biologically active. The ED as determined by dose-dependent induction of alkaline phosphatase activity with C2C12 cells is in the range of 2-12 µg/ml.
Results: 1.02.0 g/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 15.7 kDa
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Sterile filtered and lyophilized with no additives
Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in HO. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or 20°C for future use.
Amino acid sequence: N/A