CUR-61414 | 2743

CUR-61414 is a potent, cell-permeable , Hedgehog signaling pathway inhibitor (IC₅₀ = 100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.

CUR-61414 is a potent, cell-permeable , Hedgehog signaling pathway inhibitor (IC₅₀ = 100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.

2743 | CUR-61414 DataSheet

Alternate Name/Synonyms: N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide

Appearance: Tan solid

Formulation: N/A

CAS Number: 334998-36-6

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₄₂N₄O₅

Molecular Weight: 550.69

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (40 mg/ml) or EtOH (20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent Hedgehog signaling pathway inhibitor

MDL Number: N/A

PubChem CID: 9829015

SMILES: CC(C)(C)CC(=O)N(CC1=CC(=CC=C1)OC)C2CC(N(C2)CC3=CC4=C(C=C3)OCO4)C(=O)N5CCNCC5

InChi: InChI=1S/C31H42N4O5/c1-31(2,3)17-29(36)35(19-22-6-5-7-25(14-22)38-4)24-16-26(30(37)33-12-10-32-11-13-33)34(20-24)18-23-8-9-27-28(15-23)40-21-39-27/h5-9,14-15,24,26,32H,10-13,16-21H2,1-4H3

InChi Key: WPHXYKUPFJRJDK-UHFFFAOYSA-N