Curcumin, Curcuma longa (High Purity) | 1850

Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC₅₀ = 8 µM) and cyclooxygenase (COX) (IC₅₀ = 52 µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC₅₀ of ~25 µM. Does not affect p300/CREB binding protein-associated factor (PCAF).

Curcumin, Curcuma longa (High Purity) is an antioxidant and dual inhibitor of 5-lipoxygenase (IC₅₀ = 8 µM) and cyclooxygenase (COX) (IC₅₀ = 52 µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors.

1850 | Curcumin, Curcuma longa (High Purity) DataSheet

Alternate Name/Synonyms: 1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane

Appearance: Orange-yellow solid

Formulation: N/A

CAS Number: 458-37-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₀O₆

Molecular Weight: 368.38

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (25 mg/ml) or EtOH (10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent antioxidant

MDL Number: MFCD00008365

PubChem CID: 969516

SMILES: COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

InChi: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChi Key: VFLDPWHFBUODDF-FCXRPNKRSA-N