CXCR2 Antibody | 19-026

CXCR2 Antibody | 19-026 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant protein of human CXCR2.

Research Area: Apoptosis, Cell Cycle, Immunology, Signal Transduction

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: A-549

Positive Control 2: HepG2

Positive Control 3: mouse spleen

Positive Control 4: mouse lung

Positive Control 5: rat spleen

Positive Control 6: rat lung

Molecular Weight: Observed: 41kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: Cxcr2, mIL-8RH, interleukin-8 receptor type B, interleukin 8 receptor, beta, IL-8Rh, IL-8rb, Il8rb, IL8RA, IL-8R B, IL-8 receptor alpha chain, high affinity interleukin-8 receptor B, GRO/MGSA receptor, Gpcr16, CXC-R2, CXCR-2, C-X-C chemokine receptor type 2, Cmkar2, chemokine (C-X-C) receptor 2, chemokine (C-X-C motif) receptor 2, CDw128, CD128, IL8RB

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8) . It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA) , a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.