α-Cyano-4-hydroxycinnamic acid | B2162

α-Cyano-4-hydroxycinnamate (4-CIN) is a monocarboxylate transporter (MCT) inhibitor. Displays antitumor and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Also blocks lactate efflux from glioma cells and sensitizes cells to irradiation.

α-Cyano-4-hydroxycinnamate (4-CIN) is a monocarboxylate transporter (MCT) inhibitor. Displays antitumor and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Also blocks lactate efflux from glioma cells and sensitizes cells to irradiation.

B2162 | α-Cyano-4-hydroxycinnamic acid DataSheet

Alternate Name/Synonyms: α-CCA; 4-HCCA; CHCA; NSC173138; 4-CIN

Appearance: Yellow solid

Formulation: N/A

CAS Number: 28166-41-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₇NO₃

Molecular Weight: 189.17

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A monocarboxylate transporter (MCT) inhibitor

MDL Number: MFCD00004204

PubChem CID: 5328791

SMILES: C1=CC(=CC=C1C=C(C#N)C(=O)O)O

InChi: InChI=1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChi Key: AFVLVVWMAFSXCK-VMPITWQZSA-N