Cyclin H (Phospho-T315) polyclonal Antibody | BS64522

Cyclin H (Phospho-T315) polyclonal Antibody | BS64522 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Cyclin H belongs to the highly conserved cyclin family, and are regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin H forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, and thus functions as a CDK-activating kinase (CAK) . Cyclin H and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Cyclin H (Phospho-T315)  polyclonal Antibody detects endogenous levels of Cyclin H protein only when phosphorylated at Thr315.

Molecular Weight: ~ 37 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cyclin-H; MO15-associated protein; p34; p37; CCNH

Immunogen: Synthetic phosphopeptide derived from human Cyclin H around the phosphorylation site of Threonine 315.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Contribution of Soluble Factors to EMT,