Cyclopamine tartrate | 2518

Cyclopamine tartrate is a water-soluble derivative of the Hedgehog (Hh) signaling pathway inhibitor Cyclopamine (Cyc) (Cat. No.1578). Displays higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC₀ = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). CycT-treated mice shows tumor shrinkage and decreased expression of Hh target genes.

Cyclopamine tartrate is a water-soluble derivative of the Hedgehog (Hh) signaling pathway inhibitor Cyclopamine (Cyc) (Cat. No.1578). Displays higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC₀ = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). CycT-treated mice shows tumor shrinkage and decreased expression of Hh target genes.

2518 | Cyclopamine tartrate DataSheet

Alternate Name/Synonyms: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol tartrate; 11-Deoxojervine Tartrate; (3β,23β)-17,23-Epoxy- veratraman-3-ol Tartrate; 11-Deoxyjervine Tartrate; CycT

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1178510-81-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₅₈H₈₈N₂O₁₀

Molecular Weight: 973.32

Cell-Permeable?: No

Purity: ≥98%

Solubilities: H₂O (~2 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A Hedgehog (Hh) signaling pathway inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O[C@@H]1CC2=CC[C@]3([H])[C@]([C@@]2(C)CC1)([H])CC4=C(C)[C@@]5(O[C@@]6([H])[C@@]([C@H]5C)([H])NC[C@@H](C)C6)CC[C@@]34[H].[.C4H6O6]

InChi: N/A

InChi Key: N/A