CYP2R1 Antibody (Center) [APR32519G]

CYP2R1 Antibody (Center) [APR32519G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This CYP2R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human CYP2R1.

Cellular Localisation: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein

Molecular Weight: 57359

Clone: Polyclonal

Gene Name: CYP2R1

Gene ID: 120227

Function: A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D (2) and D (3) (calciol) (PubMed:12867411, PubMed:15465040, PubMed:18511070) . Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D (2) (doxercalciferol) and 1alpha-hydroxyvitamin D (3) (alfacalcidol) forming 25-hydroxy derivatives (PubMed:15465040, PubMed:18511070) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:12867411, PubMed:15465040, PubMed:18511070) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Vitamin D 25-hydroxylase, Cytochrome P450 2R1, CYP2R1