LBD
CYP2R1 Antibody (Center) [APR32519G]
- SKU:
- LBD-APR32519G
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Description
CYP2R1 Antibody (Center) [APR32519G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This CYP2R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human CYP2R1.
Cellular Localisation: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
Molecular Weight: 57359
Clone: Polyclonal
Gene Name: CYP2R1
Gene ID: 120227
Function: A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D (2) and D (3) (calciol) (PubMed:12867411, PubMed:15465040, PubMed:18511070) . Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D (2) (doxercalciferol) and 1alpha-hydroxyvitamin D (3) (alfacalcidol) forming 25-hydroxy derivatives (PubMed:15465040, PubMed:18511070) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:12867411, PubMed:15465040, PubMed:18511070) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: Vitamin D 25-hydroxylase, Cytochrome P450 2R1, CYP2R1