CYP2R1 Polyclonal Antibody | BS65875

CYP2R1 Polyclonal Antibody | BS65875 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Horse,Rabbit,

Application: WB,

Application Range: WB=1:500-2000

Background: CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. Defects in CYP2R1 are a cause of 25-hydroxyvitamin D (3) deficiency, also known as pseudovitamin D (3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity and low levels of 25-hydroxyvitamin D.

Storage & Stability: Store at 4°C short term. Aliquot and store at -48°C long term. Avoid freeze-thaw cycles.

Specificity: CYP2R1 Polyclonal Antibody detects endogenous levels of CYP2R1 protein.

Molecular Weight: ~53kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC 1.14.13.15; MGC4663; Vitamin D 25 hydroxylase.

Immunogen: KLH conjugated synthetic peptide derived from human CYP2R1:251-350/501

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: