BW
CYP2R1 Polyclonal Antibody | BS65875
- SKU:
- BW-BS65875
- Availability:
- Usually ships in 5 working days
Description
CYP2R1 Polyclonal Antibody | BS65875 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat,Dog,Pig,Horse,Rabbit,
Application: WB,
Application Range: WB=1:500-2000
Background: CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. Defects in CYP2R1 are a cause of 25-hydroxyvitamin D (3) deficiency, also known as pseudovitamin D (3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity and low levels of 25-hydroxyvitamin D.
Storage & Stability: Store at 4°C short term. Aliquot and store at -48°C long term. Avoid freeze-thaw cycles.
Specificity: CYP2R1 Polyclonal Antibody detects endogenous levels of CYP2R1 protein.
Molecular Weight: ~53kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC 1.14.13.15; MGC4663; Vitamin D 25 hydroxylase.
Immunogen: KLH conjugated synthetic peptide derived from human CYP2R1:251-350/501
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: affinity purified by Protein A
Pathway: