Cysmethynil | B2544

Cysmethynil is a potent, time-dependent inhibitor of Icmt (IC₅₀= <200 nM). It acts as a competitive inhibitor with respect to the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to S-adenosylmethionine (Ki = 0.14 µM for the final complex). It does not inhibit other enzymes in the prenylation pathway (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 µM, or related methyltransferases.

Cysmethynil is a potent, time-dependent inhibitor of Icmt (IC₅₀= <200 nM). It acts as a competitive inhibitor with respect to the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to S-adenosylmethionine (Ki = 0.14 µM for the final complex). It does not inhibit other enzymes in the prenylation pathway (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 µM, or related methyltransferases.

B2544 | Cysmethynil DataSheet

Alternate Name/Synonyms: Icmt Inhibitor; 5-(3-methylphenyl)-1-octyl-1H-indole-3-acetamide

Appearance: Crystalline solid

Formulation:

CAS Number: 851636-83-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₂N₂O

Molecular Weight: 376.5

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >5 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Isoprenylcysteine carboxyl methyltransferase (Icmt) inhibitor

MDL Number:

PubChem CID: 6918831

SMILES: CCCCCCCCN1C=C(C2=C1C=CC(=C2)C3=CC(=CC=C3)C)CC(=O)N

InChi: InChI=1S/C25H32N2O/c1-3-4-5-6-7-8-14-27-18-22(17-25(26)28)23-16-21(12-13-24(23)27)20-11-9-10-19(2)15-20/h9-13,15-16,18H,3-8,14,17H2,1-2H3,(H2,26,28)

InChi Key: QIXBOOVPFRZHQQ-UHFFFAOYSA-N