Description
Cysmethynil is a potent, time-dependent inhibitor of Icmt (IC₅₀= <200 nM). It acts as a competitive inhibitor with respect to the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to S-adenosylmethionine (Ki = 0.14 µM for the final complex). It does not inhibit other enzymes in the prenylation pathway (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 µM, or related methyltransferases.
Cysmethynil is a potent, time-dependent inhibitor of Icmt (IC₅₀= <200 nM). It acts as a competitive inhibitor with respect to the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to S-adenosylmethionine (Ki = 0.14 µM for the final complex). It does not inhibit other enzymes in the prenylation pathway (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 µM, or related methyltransferases.
Alternate Name/Synonyms: Icmt Inhibitor; 5-(3-methylphenyl)-1-octyl-1H-indole-3-acetamide
Appearance: Crystalline solid
Formulation:
CAS Number: 851636-83-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₃₂N₂O
Molecular Weight: 376.5
Cell-Permeable?: True
Purity: ≥98%
Solubilities: >5 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: Isoprenylcysteine carboxyl methyltransferase (Icmt) inhibitor
MDL Number:
PubChem CID: 6918831
SMILES: CCCCCCCCN1C=C(C2=C1C=CC(=C2)C3=CC(=CC=C3)C)CC(=O)N
InChi: InChI=1S/C25H32N2O/c1-3-4-5-6-7-8-14-27-18-22(17-25(26)28)23-16-21(12-13-24(23)27)20-11-9-10-19(2)15-20/h9-13,15-16,18H,3-8,14,17H2,1-2H3,(H2,26,28)
InChi Key: QIXBOOVPFRZHQQ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |