Cytarabine | B2661

Cytarabine is a cytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. It is triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases α and β (Kis = 4 and 32 µM, respectively). Cytarabine is effective in the treatment of leukemias. It can also have antiviral actions on certain types of viruses.

Cytarabine is a cytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. It is triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases α and β (Kis = 4 and 32 µM, respectively). Cytarabine is effective in the treatment of leukemias. It can also have antiviral actions on certain types of viruses.

B2661 | Cytarabine DataSheet

Alternate Name/Synonyms: NSC 287459; 4-amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone; NSC 63878; 1-β-D-Arabinofuranosylcytosine; U-19920A

Appearance: White solid

Formulation:

CAS Number: 147-94-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₉H₁₃N₃O₅

Molecular Weight: 243.22

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~40 mg/ml in Water

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An anti-leukemic and antiviral agent

MDL Number: MFCD00066487

PubChem CID: 6253

SMILES: O[C@@H]1[C@H](N2C(N=C(N)C=C2)=O)O[C@H](CO)[C@H]1O

InChi: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1

InChi Key: UHDGCWIWMRVCDJ-CCXZUQQUSA-N