Description
Cytarabine is a cytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. It is triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases α and β (Kis = 4 and 32 µM, respectively). Cytarabine is effective in the treatment of leukemias. It can also have antiviral actions on certain types of viruses.
Cytarabine is a cytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. It is triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases α and β (Kis = 4 and 32 µM, respectively). Cytarabine is effective in the treatment of leukemias. It can also have antiviral actions on certain types of viruses.
Alternate Name/Synonyms: NSC 287459; 4-amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone; NSC 63878; 1-β-D-Arabinofuranosylcytosine; U-19920A
Appearance: White solid
Formulation:
CAS Number: 147-94-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₉H₁₃N₃O₅
Molecular Weight: 243.22
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~40 mg/ml in Water
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An anti-leukemic and antiviral agent
MDL Number: MFCD00066487
PubChem CID: 6253
SMILES: O[C@@H]1[C@H](N2C(N=C(N)C=C2)=O)O[C@H](CO)[C@H]1O
InChi: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
InChi Key: UHDGCWIWMRVCDJ-CCXZUQQUSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |