BW
Cytokeratin 1 polyclonal Antibody | BS90373
- SKU:
- BW-BS90373
- Availability:
- Usually ships in 5 working days
Description
Cytokeratin 1 polyclonal Antibody | BS90373 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB IHC
Application Range: WB:1:1,000 IHC:1:100-1:500
Background: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins constitute up to 85% of a mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10-nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and they aid in the characterization of malignant tumors. Cytokeratin 1 is highly expressed in several malignancies including epithelioid hemangioendohtheliomas, angiosarcomas, schwannomas, epithelioid sarcomas and synodal sarcomas. The gene encoding human Cytokeratin 1 maps to chromosome 12q13.13. Mutations in the gene encoding human Cytokeratin 1 lead to abnormal filament associations and epidermolytic hyperkeratosis.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Cytokeratin 1 polyclonal Antibody detects endogenous levels of Cytokeratin 1 protein.
Molecular Weight: 72 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: CK-1, K1, KRT1, 67 kDa cytokeratin, CK-1, CK1, Cytokeratin-1, Cytokeratin1, EHK, EHK1, Epidermolytic hyperkeratosis 1, EPPK, Hair alpha protein, K1, K2C1, Keratin, Keratin type II cytoskeletal 1, Keratin-1, Keratin1, KRT 1, Krt1, KRT1A, NEPPK, type II cytoskeletal 1, Type II keratin Kb1, Type-II keratin Kb1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: