Additional Information
Short Description: |
LRRK2 inhibitor |
Research Area: |
Cell Signaling |
Alternative Name(s): |
N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide hydrochloride |
Category: |
Small Molecules |
Product Type: |
Inhibitor |
CAS No.: |
1191911-27-9 |
Molecular Formula: |
C22H26Cl2N6O4S |
Molecular Weight: |
541,5 |
Source: |
Synthetic |
Purity: |
>98% |
Solubility: |
Soluble to 100 mM in DMSO |
Appearance: |
Yellow solid |
Storage: |
-20ºC |
Shipping: |
Shipped Ambient |
SMILES: |
COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl |
InChI: |
InChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H |
InChIKey: |
KWCBHUPLQMUKAF-UHFFFAOYSA-N |
Field of Use: |
For in vitro research use only. |
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CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC₅₀ values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). CZC-54252 attenuates...
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