DAGLB Antibody (Center) [APR32688G]

DAGLB Antibody (Center) [APR32688G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This DAGLB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 491-518 amino acids from the Central region of human DAGLB.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 73732

Clone: Polyclonal

Gene Name: DAGLB

Gene ID: 221955

Function: Lipase that catalyzes the hydrolysis of arachidonic acid (AA) -esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX) -mediated eicosanoid production (PubMed:14610053) . Preferentially hydrolyzes DAGs at the sn-1 position in a calcium- dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053) . Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Sn1-specific diacylglycerol lipase beta, DGL-beta, 311-, KCCR13L, DAGLB