LBD
DAGLB Antibody (Center) [APR32688G]
- SKU:
- LBD-APR32688G
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Description
DAGLB Antibody (Center) [APR32688G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This DAGLB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 491-518 amino acids from the Central region of human DAGLB.
Cellular Localisation: Cell membrane; Multi-pass membrane protein
Molecular Weight: 73732
Clone: Polyclonal
Gene Name: DAGLB
Gene ID: 221955
Function: Lipase that catalyzes the hydrolysis of arachidonic acid (AA) -esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX) -mediated eicosanoid production (PubMed:14610053) . Preferentially hydrolyzes DAGs at the sn-1 position in a calcium- dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053) . Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, FC
Dilution: WB--1:1000 FC--1:10~50
Synonyms: Sn1-specific diacylglycerol lipase beta, DGL-beta, 311-, KCCR13L, DAGLB