Daminozide | 2438

A highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC₅₀ values of 1.5, 0.55, and 2.1 μM, respectively. When tested for inhibition of other demethylase subfamily members (KDM3, KDM4, KDM5, KDM6) and other 2OG oxygenases (FIH, PHD2, BBOX1), daminozide was considerably less potent (IC₅₀’s > 100 μM).

Daminozide is a highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC₅₀ values of 1.5, 0.55, and 2.1 μM, respectively.

2438 | Daminozide DataSheet

Alternate Name/Synonyms: 1-​(2,​2-​dimethylhydrazide)-​butanedioic acid; Succinic acid mono(2,2-dimethylhydrazide)

Appearance: White solid

Formulation: N/A

CAS Number: 1596-84-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₁₂N₂O₃

Molecular Weight: 160.17

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~15 mg/ml) or EtOH (~ 3 mg/ml) or H₂O (~ 15 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A histone demethylase inhibitor

MDL Number: MFCD00002787

PubChem CID: 15331

SMILES: CN(C)NC(=O)CCC(=O)O

InChi: InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11)

InChi Key: NOQGZXFMHARMLW-UHFFFAOYSA-N