Description
A highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC₅₀ values of 1.5, 0.55, and 2.1 μM, respectively. When tested for inhibition of other demethylase subfamily members (KDM3, KDM4, KDM5, KDM6) and other 2OG oxygenases (FIH, PHD2, BBOX1), daminozide was considerably less potent (IC₅₀’s > 100 μM).
Daminozide is a highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC₅₀ values of 1.5, 0.55, and 2.1 μM, respectively.
Alternate Name/Synonyms: 1-(2,2-dimethylhydrazide)-butanedioic acid; Succinic acid mono(2,2-dimethylhydrazide)
Appearance: White solid
Formulation: N/A
CAS Number: 1596-84-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₆H₁₂N₂O₃
Molecular Weight: 160.17
Cell-Permeable?: Yes
Purity: ≥95%
Solubilities: DMSO (~15 mg/ml) or EtOH (~ 3 mg/ml) or H₂O (~ 15 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A histone demethylase inhibitor
MDL Number: MFCD00002787
PubChem CID: 15331
SMILES: CN(C)NC(=O)CCC(=O)O
InChi: InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11)
InChi Key: NOQGZXFMHARMLW-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |