Description
Damnacanthal is a potent and inhibitor of p56lck tyrosine kinase and inhibits autophosphorylation with IC50 of 17 nM and phosphorylation of exogenous substrates with IC50 of 620 nM in cell free assays. Damnacanthal Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Mobilizes intracellular Ca2+ in dermal fibroblasts and inhibits Ras function. Also inhibits LIMK1/2, as well as migration and invasion of breast cancer cells in vitro.
Damnacanthal is a potent and inhibitor of p56lck tyrosine kinase and inhibits autophosphorylation with IC50 of 17 nM and phosphorylation of exogenous substrates with IC50 of 620 nM in cell free assays. Damnacanthal Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC.
B1094 | Damnacanthal DataSheet
Alternate Name/Synonyms: 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
Appearance: Pale orange solid
Formulation: N/A
CAS Number: 477-84-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₆H₁₀O₅
Molecular Weight: 282.25
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective inhibitor of p56lck tyrosine kinase
MDL Number: N/A
PubChem CID: 2948
SMILES: COC1=C2C(=CC(=C1C=O)O)C(=O)C3=CC=CC=C3C2=O
InChi: InChI=1S/C16H10O5/c1-21-16-11(7-17)12(18)6-10-13(16)15(20)9-5-3-2-4-8(9)14(10)19/h2-7,18H,1H3
InChi Key: IPDMWUNUULAXLU-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |