(DANRE) hspa8 Antibody (C-term) [APR33329G]

(DANRE) hspa8 Antibody (C-term) [APR33329G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: Zf

Specificity: This DANRE hspa8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 528-562 amino acids from the C-terminal region of DANRE hspa8.

Cellular Localisation: N/A

Molecular Weight: 70974

Clone: Polyclonal

Gene Name: hspa8

Gene ID: N/A

Function: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Heat shock cognate 71 kDa protein, Heat shock 70 kDa protein 8, hspa8, hsc70