(DANRE) aplnra Antibody (C-Term) [APR33114G]

(DANRE) aplnra Antibody (C-Term) [APR33114G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: Zf

Specificity: This DANRE aplnra antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 343-377 amino acids from the human region of DANRE aplnra.

Cellular Localisation: Cell membrane {ECO:0000250|UniProtKB:P79960}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P79960} Note=Internalized to the cytoplasm after exposure to apelin (apln) After exposure to apelin receptor early endogenous ligand (apela), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane {ECO:0000250|UniProtKB:P35414, ECO:0000250|UniProtKB:P79960}

Molecular Weight: 40649

Clone: Polyclonal

Gene Name: aplnra

Gene ID: 561935

Function: Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:17336906, PubMed:24316148, PubMed:24407481) . Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (PubMed:17336906, PubMed:24316148, PubMed:24407481, PubMed:26017639) . Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (PubMed:26017639) . May promote sinus venosus (SV) -derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity) . Required for cardiovascular development, particularly for intersomitic vein angiogenesis by acting as a receptor for apln hormone (By similarity) . Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure (By similarity) . Acts redundantly with agtrl1b in heart development (PubMed:17336906) .

Summary: Tissue Location: First expressed before epiboly in dorsal precursors. During epiboly, expressed in the enveloping layer, yolk syncytial layer and migrating mesendoderm. During segmentation stages, expressed in epithelial structures such as adaxial cells, border cells of the newly formed somites, developing lens, otic vesicles and venous vasculature.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Apelin receptor A, Angiotensin II receptor-like 1a, Angiotensin receptor-like 1a, G-protein coupled receptor APJ A, aplnra, agtrl1 {ECO:0000312|EMBL:ABI994701}, agtrl1a