Dapagliflozin | 9452

Dapagliflozin is a selective SGLT (sodium-glucose cotransporter) inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC₅₀ = 1.1 nM) over SGLT1 (Ki = 390 nM). An antidiabetic agent.

Dapagliflozin is a selective SGLT (sodium-glucose cotransporter) inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC₅₀ = 1.1 nM) over SGLT1 (Ki = 390 nM). An antidiabetic agent.

9452 | Dapagliflozin DataSheet

Alternate Name/Synonyms: (1S)-​1,​5-​anhydro-​1-​C-​[4-​chloro-​3-​[(4-​ethoxyphenyl)methyl]phenyl]-​D-​glucitol

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 461432-26-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₁H₂₅ClO₆

Molecular Weight: 408.87

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~80 mg/ml) or EtOH (~30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective selective SGLT-2 (sodium-glucose cotransporter 2) inhibitor

MDL Number: MFCD13182359

PubChem CID: 9887712

SMILES: CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl

InChi: InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1

InChi Key: JVHXJTBJCFBINQ-ADAARDCZSA-N