Description
Dapagliflozin is a selective SGLT (sodium-glucose cotransporter) inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC₅₀ = 1.1 nM) over SGLT1 (Ki = 390 nM). An antidiabetic agent.
Dapagliflozin is a selective SGLT (sodium-glucose cotransporter) inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC₅₀ = 1.1 nM) over SGLT1 (Ki = 390 nM). An antidiabetic agent.
9452 | Dapagliflozin DataSheet
Alternate Name/Synonyms: (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 461432-26-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₁H₂₅ClO₆
Molecular Weight: 408.87
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~80 mg/ml) or EtOH (~30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective selective SGLT-2 (sodium-glucose cotransporter 2) inhibitor
MDL Number: MFCD13182359
PubChem CID: 9887712
SMILES: CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl
InChi: InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
InChi Key: JVHXJTBJCFBINQ-ADAARDCZSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |