DB07268 | B1134

DB07268 is a potent and selective JNK1 inhibitor with (IC₅₀ = 9 nM). DB07268 displays some degree of selectivity over quite a few kinases with the exceptions of CHK1, CK2, and PLK. Although DB07268 shows submicromolar potency against these three kinases, it still appears to exhibit at least 70- to 90-fold greater potency against JNK1 than CHK1, CK2, and PLK.

DB07268 is a potent and selective JNK1 inhibitor with (IC₅₀ = 9 nM). DB07268 displays some degree of selectivity over quite a few kinases with the exceptions of CHK1, CK2, and PLK. Although DB07268 shows submicromolar potency against these three kinases, it still appears to exhibit at least 70- to 90-fold greater potency against JNK1 than CHK1, CK2, and PLK.

B1134 | DB07268 DataSheet

Alternate Name/Synonyms: 2-[[2-(3-hydroxyanilino)pyrimidin-4-yl]amino]benzamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 929007-72-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₅N₅O₂

Molecular Weight: 321.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>3 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent JNK1 inhibitor

MDL Number: N/A

PubChem CID: 16058637

SMILES: C1=CC=C(C(=C1)C(=O)N)NC2=NC(=NC=C2)NC3=CC(=CC=C3)O

InChi: 1S/C17H15N5O2/c18-16(24)13-6-1-2-7-14(13)21-15-8-9-19-17(22-15)20-11-4-3-5-12(23)10-11/h1-10,23H,(H2,18,24)(H2,19,20,21,22)

InChi Key: QHPKKGUGRGRSGA-UHFFFAOYSA-N