Description
DB07268 is a potent and selective JNK1 inhibitor with (IC₅₀ = 9 nM). DB07268 displays some degree of selectivity over quite a few kinases with the exceptions of CHK1, CK2, and PLK. Although DB07268 shows submicromolar potency against these three kinases, it still appears to exhibit at least 70- to 90-fold greater potency against JNK1 than CHK1, CK2, and PLK.
DB07268 is a potent and selective JNK1 inhibitor with (IC₅₀ = 9 nM). DB07268 displays some degree of selectivity over quite a few kinases with the exceptions of CHK1, CK2, and PLK. Although DB07268 shows submicromolar potency against these three kinases, it still appears to exhibit at least 70- to 90-fold greater potency against JNK1 than CHK1, CK2, and PLK.
Alternate Name/Synonyms: 2-[[2-(3-hydroxyanilino)pyrimidin-4-yl]amino]benzamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 929007-72-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₅N₅O₂
Molecular Weight: 321.34
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>3 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent JNK1 inhibitor
MDL Number: N/A
PubChem CID: 16058637
SMILES: C1=CC=C(C(=C1)C(=O)N)NC2=NC(=NC=C2)NC3=CC(=CC=C3)O
InChi: 1S/C17H15N5O2/c18-16(24)13-6-1-2-7-14(13)21-15-8-9-19-17(22-15)20-11-4-3-5-12(23)10-11/h1-10,23H,(H2,18,24)(H2,19,20,21,22)
InChi Key: QHPKKGUGRGRSGA-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |