Description
dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC₅₀ of 14 nM. dBET6 prompts a collapse of global elongation that phenocopies CDK9 inhibition. Displays antitumor activity.
dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC₅₀ of 14 nM. dBET6 prompts a collapse of global elongation that phenocopies CDK9 inhibition. Displays antitumor activity.
Alternate Name/Synonyms: 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)-acetamide
Appearance: Crystalline solid
Formulation:
CAS Number: 1950634-92-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₄₂H₄₅ClN₈O₇S
Molecular Weight: 841.38
Cell-Permeable?: True
Purity: ≥98%
Solubilities: in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A novel degrader of BET bromodomain proteins
MDL Number:
PubChem CID: 121427831
SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)C7=CC=C(C=C7)Cl)C
InChi: InChI=1S/C42H45ClN8O7S/c1-23-24(2)59-42-35(23)37(26-13-15-27(43)16-14-26)46-29(38-49-48-25(3)50(38)42)21-33(53)44-19-8-6-4-5-7-9-20-45-34(54)22-58-31-12-10-11-28-36(31)41(57)51(40(28)56)30-17-18-32(52)47-39(30)55/h10-16,29-30H,4-9,17-22H2,1-3H3,(H,44,53)(H,45,54)(H,47,52,55)/t29-,30?/m0/s1
InChi Key: JGQPZPLJOBHHBK-UFXYQILXSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |