DC-SIGN Antibody [5D7] | PM-2347

DC-SIGN Antibody [5D7] | PM-2347 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.

Research Area: Infectious Disease

Tested Application: E, WB, IHC-P

Application: DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 - 2 μg/mL and in immunohistochemistry at 5 - 10 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Specificiy: N/A

Positive Control 1: Cat. No. 1384 - Human Uterus Tissue Lysate

Positive Control 2: Cat. No. 1369 - Human Lymph node Tissue Lysate

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 44 kDa
Observed: 47 kDa

Validation: N/A

Isoform: N/A

Purification: DC-SIGN Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Clonality: Monoclonal

Clone: 5D7

Isotype: IgG1

Conjugate: Unconjugated

Physical State: Liquid

Buffer: DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: DC-SIGN monoclonal antibody can be stored at -20˚C, stable for one year.

Alternate Name: DC-SIGN Antibody [5D7] : CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.