DCAMKL1 polyclonal Antibody | BS90395

DCAMKL1 polyclonal Antibody | BS90395 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC

Application Range: WB:1:500-1:1,000 IHC:1:50-1:200

Background: Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to β-subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortinlike and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: DCAMKL1 polyclonal Antibody detects endogenous levels of DCAMKL1 protein.

Molecular Weight: 82 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: DCLK1, Calcium/calmodulin-dependent protein kinase type I-like CPG16, CL1, CLICK1, Cpg16, DCDC3A, Dcl, Dclk, Dclk1, DCLK1, Doublecortin domain-containing protein 3A, Doublecortin-like and CAM kinase-like 1, Doublecortin-like kinase 1, KIAA0369, Serine/threonine-protein kinase DCAMKL1, Serine/threonine-protein kinase DCLK1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: