DCC (F465) polyclonal Antibody | BS3232

DCC (F465) polyclonal Antibody | BS3232 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC IF

Application Range: IHC: 1:50~1:200 IF: 1:50~1:200

Background: DCC (deleted in colorectal cancer) was first identified as a candidate tumor suppressor gene based on its absence or reduced expression in the majority of colorectal cancers. Loss of DCC expression was subsequently observed in cancers of the breast, endometrium, brain, pancreas and prostate, as well as in leukemias, neuroblastomas and male germ cell cancers. DCC is a 1447 amino acid transmembrane protein with highest expression in developing brain and neural tube and is suspected to play a role in mediating directional migration in the developing nervous system. Netrin-1, a chemoattractant for commissural axons in the spinal cord, has been identified as a ligand for DCC.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DCC (F465) polyclonal Antibody detects endogenous levels of DCC protein

Molecular Weight: ~ 158 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Netrin receptor DCC,Colorectal cancer suppressor,Immunoglobulin superfamily DCC subclass member 1,Tumor suppressor protein DCC,IGDCC1,DCC

Immunogen: Synthetic peptide, corresponding to amino acids 450-500 of Human DCC.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: