DDX41 Antibody | 7349

DDX41 Antibody | 7349 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: DDX41 antibody was raised against a 17 amino acid peptide near the amino terminus of human DDX41.
The immunogen is located within amino acids 230 - 280 of DDX41.

Research Area: Innate Immunity

Tested Application: E, WB, IHC-P, IF

Application: DDX41 antibody can be used for detection of DDX41 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Specificiy: At least two isoforms of DDX41 are known to exist; this antibody will detect both isoforms.

Positive Control 1: Cat. No. 1463 - Rat Brain Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 68 kDa
Observed: 70 kDa

Validation: N/A

Isoform: N/A

Purification: DDX41 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: DDX41 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: DDX41 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: DDX41 Antibody: ABS, ABS, Probable ATP-dependent RNA helicase DDX41, DEAD box protein 41

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: DDX41 Antibody: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DDX41, also known as Abstrakt, interacts with and regulates the expression of sorting nexin-2 (SNX2) , a protein involved in protein sorting in the trans-Golgi network. Recent evidence suggests that DDX41 also plays a role in the innate immune response by sensing intracellular viral DNA, triggering TBK1 and IRF3 activation, leading to a type I interferon immune response.