DDX54 polyclonal Antibody | BS61585

DDX54 polyclonal Antibody | BS61585 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB: 1:500~1:1000

Background: DEAD-box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure and ribosome/spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX54 (DEAD polypeptide 54), also known as DP97, is an 881 amino acid protein that contains 2 bipartite nuclear localization signals, 3 nuclear receptor boxes (LXXLL motifs), a potential CoRNR box, and several stretches of glutamate and lysine residues. DDX54 is ubiquitously expressed, with highest expression in pancreas and lung. DDX54 co-localizes with ERα to structures in the nucleoplasm. DDX54 represses ERα transcriptional activity and acts as a nuclear receptor co-repressor against ERβ, progesterone, glucocorticoid and RARα

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: DDX54 polyclonal Antibody detects endogenous levels of DDX54 protein.

Molecular Weight: ~ 98 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ATP-dependent RNA helicase DDX54 ; ATP-dependent RNA helicase DP97; DEAD box RNA helicase 97 kDa; DEAD box protein 54

Immunogen: Synthetic peptide, corresponding to amino acids 602-646 of Human DDX54

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Pathway: