Description
DDX58 polyclonal Antibody | BS6819 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human
Application: WB,IHC,IF
Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Background: Retinoic acid inducible gene I (RIG-I) is a 925 amino acid, interferon-inducible cellular DExD/H box RNA helicase that activates type I interferon (IFN), an important effector of the innate immune system that is sensitive to these dsRNA viruses. dsRNA is normally present in very low quantities in cells, so when a virus is present, the elevated levels of dsRNA act as a sign telling RIG-I to activate the production of IFN. RIG-I does this by using its helicase domain to bind to viral dsRNA, thus transmitting the activation signal for IFN through IkB kinase-related kinases and inducing IFN expression.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: DDX58 polyclonal Antibody detects endogenous levels of DDX58 protein.
Molecular Weight: ~ 107 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Probable ATP-dependent RNA helicase DDX58; DEAD box protein 58; RIG-I-like receptor 1; RLR-1; RLR1; Retinoic acid-inducible gene 1 protein; RIG-1; RIG1; Retinoic acid-inducible gene I protein; RIG-I; RIGI;
Immunogen: Recombinant full length Human DDX58.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Tumor-Infiltrating Immune Cell Marker Guide,Contribution of ECM and Cytoskeletal Factors to EMT,