DEDD2 Antibody (Center) [APR33389G]

DEDD2 Antibody (Center) [APR33389G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This DEDD2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-193 amino acids from the Central region of human DEDD2.

Cellular Localisation: Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli

Molecular Weight: 36179

Clone: Polyclonal

Gene Name: DEDD2

Gene ID: 162989

Function: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

Summary: Tissue Location: Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G- 361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: DNA-binding death effector domain-containing protein 2, DED-containing protein FLAME-3, FADD-like anti-apoptotic molecule 3, DEDD2, FLAME3