LBD
DEF6 Antibody (C-term) [APR15716G]
- SKU:
- LBD-APR15716G
- Availability:
- Usually ships in 5 working days
Description
DEF6 Antibody (C-term) [APR15716G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This DEF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-528 amino acids from the C-terminal region of human DEF6.
Cellular Localisation: Cytoplasm. Cell membrane Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium. Note=Recruited to the plasma membrane upon binding phosphatidylinositol 3, 4, 5-trisphosphate (PubMed:15023524) . Binds to actin filaments (PubMed:15023524)
Molecular Weight: 73910
Clone: Polyclonal
Gene Name: DEF6
Gene ID: 50619
Function: Phosphatidylinositol 3, 4, 5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity) .
Summary: Tissue Location: Broadly expressed in the immune system and can be detected in T and B-cells.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Differentially expressed in FDCP 6 homolog, DEF-6, IRF4-binding protein, DEF6, IBP