Demethoxycurcumin | B2945

Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells at 25 μM. It inhibits proliferation of different cell lines such as Jurkat, U937, KBM-5 and H1299 at 25 μM. It suppresses transcriptional coactivator p300 and inhibits the Wnt/beta-catenin pathway.

Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells at 25 μM. It inhibits proliferation of different cell lines such as Jurkat, U937, KBM-5 and H1299 at 25 μM. It suppresses transcriptional coactivator p300 and inhibits the Wnt/beta-catenin pathway.

B2945 | Demethoxycurcumin DataSheet

Alternate Name/Synonyms: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione; Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin; Feruloyl-P-hydroxycinnnamoylmethane; feruloyl-p-coumaroylmethane; 1-(4-Hydroxystyryl)-3-(3-methoxy-4-hydroxystyryl)propanedial; (1E,4Z,6E)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)-7-(4-hydroxy-phenyl)-hepta-1,4,6-trien-3-one

Appearance: A crystalline solid

Formulation:

CAS Number: 24939-17-1, 22608-11-3

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₀H₁₈O₅

Molecular Weight: 338.35

Cell-Permeable?: True

Purity: 95%

Solubilities: ~0.5 mg/ml in in Ethanol, ~10 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A curcumin analogue with anti-inflammatory and anti-proliferative properties

MDL Number:

PubChem CID: 5469424

SMILES: COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O

InChi: InChI=1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+

InChi Key: HJTVQHVGMGKONQ-LUZURFALSA-N