Description
Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells at 25 μM. It inhibits proliferation of different cell lines such as Jurkat, U937, KBM-5 and H1299 at 25 μM. It suppresses transcriptional coactivator p300 and inhibits the Wnt/beta-catenin pathway.
Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells at 25 μM. It inhibits proliferation of different cell lines such as Jurkat, U937, KBM-5 and H1299 at 25 μM. It suppresses transcriptional coactivator p300 and inhibits the Wnt/beta-catenin pathway.
B2945 | Demethoxycurcumin DataSheet
Alternate Name/Synonyms: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione; Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin; Feruloyl-P-hydroxycinnnamoylmethane; feruloyl-p-coumaroylmethane; 1-(4-Hydroxystyryl)-3-(3-methoxy-4-hydroxystyryl)propanedial; (1E,4Z,6E)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)-7-(4-hydroxy-phenyl)-hepta-1,4,6-trien-3-one
Appearance: A crystalline solid
Formulation:
CAS Number: 24939-17-1, 22608-11-3
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₂₀H₁₈O₅
Molecular Weight: 338.35
Cell-Permeable?: True
Purity: 95%
Solubilities: ~0.5 mg/ml in in Ethanol, ~10 mg/ml in DMSO and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A curcumin analogue with anti-inflammatory and anti-proliferative properties
MDL Number:
PubChem CID: 5469424
SMILES: COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O
InChi: InChI=1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+
InChi Key: HJTVQHVGMGKONQ-LUZURFALSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |