Deoxyguanosine Kinase (DGUOK) Antibody (C-term) [APR15720G]

Deoxyguanosine Kinase (DGUOK) Antibody (C-term) [APR15720G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This Deoxyguanosine Kinase (DGUOK) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-271 amino acids from the C-terminal region of human Deoxyguanosine Kinase (DGUOK) .

Cellular Localisation: Mitochondrion {ECO:0000250|UniProtKB:Q9QX60}.

Molecular Weight: 32056

Clone: Polyclonal

Gene Name: DGUOK

Gene ID: 1716

Function: Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, PubMed:8706825, PubMed:11687801, PubMed:17073823, PubMed:23043144) . In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity) . Widely used as target of antiviral and chemotherapeutic agents.

Summary: Tissue Location: Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Deoxyguanosine kinase, mitochondrial, dGK, DGUOK, DGK